If it's from the same account as before then you shouldn't have to, but to prevent issues occurring I personally would do the following:
Enable Windows Firewall temporarily.
1. Uninstall all McAfee programs through "Add or Remove Programs" in Windows "Control Panel".
2. Use the MCPR tool, see this article:
How to remove supported McAfee consumer products using the McAfee Consumer Products Removal tool (MC... This will remove all McAfee remnants from your computer. (you must have Windows Vista, XP or 2000 SP4 to use this tool)
3. Launch Windows Explorer and delete all McAfee files in "Program Files" but especially in "C:\Document and Settings\<user>\Application Data" and "C:\Document and Settings\All Users\Application Data". You have to set Windows Explorer to show all hidden files and folders (Tools > Folder Options > View tab). Just delete the McAfee folders even if they are empty in all the "Application Data" folders. Can be more than one!
In Vista: C:\Program Files, C:\ProgramData and C:\Users\yourname\AppData\Roaming
If you can't find any of these files and folders don't worry.
4. Reboot and redownload/reinstall your McAfee products directly from your account at the McAfee web site. In your case it's the boxed set. Once it's registered online you can then always download from your online account if necessary. (That way it will always be the latest version).