The 2009 products are out, but only on the Australian servers for now:
http://au.mcafee.com/root/downloads.aspIt wont be too long before everyone gets them through the normal updating process.
IE8 Beta 2 causes a blank Security Center screen unless you turn on the IE7 compatibility mode in IE8, which sort of defeats the purpose. It is a known issue and as McAfee has always stated that they don't guarantee anything under beta conditions, you are on your own. Personally I would wait until IE8 is final.
Teatimer (in Spybot Search & Destroy) has always been a clash with McAfee under certain circumstances and that wont change. The same goes for any application with resident protection. The only one so far that I personally have found that doesn't clash is SpywareBlaster.
For regular anti-spyware protection I would recommend it, it's free unless you want auto-updating, and SuperAntispyware, which also has similar paid extras.
See:
http://community.mcafee.com/showthread.php?t=136913