This area is really for testing posts only....welcome.
Vista x64 is supported. But was this an upgrade from XP x64?
Try the following:
1. Uninstall all McAfee programs through "Add or Remove Programs" in Windows "Control Panel".
2. Use the MCPR tool, see this article: How to remove supported McAfee consumer products using the McAfee Consumer Products Removal tool (MC...
This will remove all McAfee remnants from your computer. (you must have Windows Vista, XP or 2000 SP4 to use this tool)
3. Launch Windows Explorer and delete all McAfee files in "Program Files" but especially in "C:\Document and Settings\<user>\Application Data" and "C:\Document and Settings\All Users\Application Data". You have to set Windows Explorer to show all hidden files and folders (Tools > Folder Options > View tab). Just delete the McAfee folders even if they are empty in all the "Application Data" folders. Can be more than one!
In Vista: C:\Program Files, C:\ProgramData and C:\Users\yourname\AppData\Roaming
Don't worry if you don't find any of those folders.
4. Reboot and redownload/reinstall your McAfee products directly from your account at the McAfee web site.
If you are McAfee direct customer, go to https://home.mcafee.com/Secure/Protected/Login.aspx
and log in to download your McAfee products.